RRAS and RASSF5

Data Source:
HPRD (in vitro, in vivo)

		RRAS	RASSF5
Description		RAS related	Ras association domain family member 5
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Extracellular Exosome	Nucleus Cytoplasm Microtubule
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding	Protein Binding Metal Ion Binding
	Biological Process	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Nucleus
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)
Interacting Genes		18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63	31 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS ITCH KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28
Entrez ID		6237	83593
HPRD ID		01299	06117
Ensembl ID		ENSG00000126458	ENSG00000266094
Uniprot IDs		A0A024QZF2 P10301	A8K5F3 Q8WWW0
PDB IDs		2FN4	4LGD 4OH8
Enriched GO Terms of Interacting Partners?
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