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RRAS and SOS1
Data Source:
HPRD
(in vivo)
RRAS
SOS1
Description
RAS related
SOS Ras/Rac guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein-containing Complex Binding
DNA Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
SH3 Domain Binding
Protein Heterodimerization Activity
Biological Process
Leukocyte Differentiation
Ras Protein Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Cell Migration
Positive Regulation Of Angiogenesis
Regulation Of Protein Kinase B Signaling
Face Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin
Positive Regulation Of Vasculogenesis
MAPK Cascade
B Cell Homeostasis
Hair Follicle Development
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of T Cell Proliferation
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Pathways
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D mediated inhibition of cell attachment and migration
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Interleukin-15 signaling
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Estimated glomerular filtration rate (
31152163
)
Pulse pressure (
27618447
)
Schizophrenia (
25056061
29483656
)
Systolic blood pressure (
27618447
)
Aseptic loosening in total joint arthroplasty (
31791832
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Interacting Genes
18 interacting genes:
ACY3
AFDN
ARAF
BCL2
EEF1A1
EPHB2
MRPL36
NAV2
NCK1
PPP2CA
RAF1
RALGDS
RAP1GDS1
RASIP1
RASSF5
SOS1
TRIM55
TRIM63
56 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
UBASH3A
ZAP70
Entrez ID
6237
6654
HPRD ID
01299
01681
Ensembl ID
ENSG00000126458
ENSG00000115904
Uniprot IDs
A0A024QZF2
P10301
G5E9C8
Q07889
PDB IDs
2FN4
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
6SCM
6SFR
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6Y44
Enriched GO Terms of Interacting Partners
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