RRAS and RALGDS

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro, two hybrid)

		RRAS	RALGDS
Description		RAS related	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Extracellular Exosome	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		6237	5900
HPRD ID		01299	03371
Ensembl ID		ENSG00000126458	ENSG00000160271
Uniprot IDs		A0A024QZF2 P10301	Q12967 Q8N4Y1
PDB IDs		2FN4	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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