BDKRB1 and MDC1

Data Source:
BioGRID (two hybrid)

		BDKRB1	MDC1
Description		bradykinin receptor B1	mediator of DNA damage checkpoint 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Peptide Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding FHA Domain Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Leukocyte Migration Inflammatory Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Response To Mechanical Stimulus Cell Migration Sensory Perception Of Pain Negative Regulation Of Cell Growth Response To Lipopolysaccharide Negative Regulation Of Blood Pressure Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Double-strand Break Repair Via Nonhomologous End Joining Intra-S DNA Damage Checkpoint
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs		Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Metabolite levels ( 23823483)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		32 interacting genes: C1orf43 CERS1 DNAJB1 GABBR1 GNAQ GRIN1 HHATL HILPDA HTT INSIG1 LAPTM4B LRRC4C MBOAT7 MDC1 NAGPA NAP1L4 NDFIP1 NF2 OAZ2 RAE1 RETREG1 RTN4 SLC25A28 SLC39A14 SLC44A2 SLC6A8 TMEM42 TMX2 TRAM1L1 TRAT1 UQCRC1 ZNF22	40 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		623	9656
HPRD ID		02639	16252
Ensembl ID		ENSG00000100739	ENSG00000137337
Uniprot IDs		P46663	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs			2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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