ROS1 and ADGRL1

Data Source:
HPRD (two hybrid)

		ROS1	ADGRL1
Description		ROS proto-oncogene 1, receptor tyrosine kinase	adhesion G protein-coupled receptor L1
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding	G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of Cell Growth Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Gene Expression Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Differentiation Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of ERK1 And ERK2 Cascade	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation
Pathways
Drugs		Entrectinib Fostamatinib
Diseases		Non-small cell lung cancer
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Lung adenocarcinoma ( 28604730) Lung cancer ( 23143601) Night sleep phenotypes ( 27126917) Pneumococcal meningitis ( 31092817) QT interval (drug interaction) ( 23459443)
Interacting Genes		7 interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3	9 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2
Entrez ID		6098	22859
HPRD ID		01295	14305
Ensembl ID		ENSG00000047936	ENSG00000072071
Uniprot IDs		P08922	O94910
PDB IDs		3ZBF 4UXL
Enriched GO Terms of Interacting Partners?
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