ADGRL1 and ROS1

Data Source:
HPRD (two hybrid)

		ADGRL1	ROS1
Description		adhesion G protein-coupled receptor L1	ROS proto-oncogene 1, receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse	Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation	Regulation Of Cell Growth Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Gene Expression Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Differentiation Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs			Entrectinib Fostamatinib
Diseases			Non-small cell lung cancer
GWAS			Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Lung adenocarcinoma ( 28604730) Lung cancer ( 23143601) Night sleep phenotypes ( 27126917) Pneumococcal meningitis ( 31092817) QT interval (drug interaction) ( 23459443)
Interacting Genes		9 interacting genes: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2	7 interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3
Entrez ID		22859	6098
HPRD ID		14305	01295
Ensembl ID		ENSG00000072071	ENSG00000047936
Uniprot IDs		O94910	P08922
PDB IDs			3ZBF 4UXL
Enriched GO Terms of Interacting Partners?
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