ROS1

Description		ROS proto-oncogene 1, receptor tyrosine kinase
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GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Membrane Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding
	Biological Process	Regulation Of Cell Growth Columnar/cuboidal Epithelial Cell Development Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Gene Expression Negative Regulation Of Gene Expression Regulation Of Phosphate Transport Cell Differentiation Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs		Entrectinib Fostamatinib
Diseases		Non-small cell lung cancer
GWAS		Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Lung adenocarcinoma ( 28604730) Lung cancer ( 23143601) Night sleep phenotypes ( 27126917) Pneumococcal meningitis ( 31092817) QT interval (drug interaction) ( 23459443)
Interacting Genes		7 interacting genes: ABL1 ADGRL1 FGFR4 IKBKG PTPN11 PTPN6 VAV3
Entrez ID		6098
HPRD ID		01295
Ensembl ID		ENSG00000047936
Uniprot IDs		P08922
PDB IDs		3ZBF 4UXL
Enriched GO Terms of Interacting Partners?
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