TRIM27 and PSMA1

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM27	PSMA1
Description		tripartite motif containing 27	proteasome 20S subunit alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Polysome Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Lipopolysaccharide Binding RNA Binding Endopeptidase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Negative Regulation Of Adaptive Immune Response Negative Regulation Of Protein Kinase Activity Spermatogenesis Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Calcium Ion Import	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 32296059 31619474 29273806) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Childhood and early adolescence aggressive behavior ( 26087016) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate in diabetes ( 31451708) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Lung cancer in ever smokers ( 28604730) Neurociticism ( 29500382) Platelet aggregation ( 20526338) Pre-treatment viral load in HIV-1 infection ( 31219150) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Social communication problems ( 24047820) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 31043756) Diastolic blood pressure ( 27841878) HDL cholesterol levels ( 32203549) High chromosomal aberration frequency (total) ( 31586183) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549 32154731) Vitamin D levels ( 25208829)
Interacting Genes		354 interacting genes: ABCA1 ABCF3 ABHD17A ACSF3 AEN AMMECR1 AMOTL2 AP1M1 ARHGEF3 ARHGEF5 ARID5A ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG3 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C1orf109 CAPN7 CARD10 CATSPER1 CBX8 CCDC102B CCDC185 CCDC187 CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDC7 CDK18 CDKL3 CFAP206 CHCHD3 CHD4 CHUK CKS1B CLK2 CNNM3 COX5B CPNE2 CPNE7 CREB5 CSRP2 CWF19L2 DBF4B DCX DDX6 DGCR6 DMRT3 DNMT1 DTNB DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4A3 EIF4E EIF4E2 ENKD1 EPC1 ERCC3 EXOC8 FAM110A FAM126A FAM126B FAM161A FAM193B FAM214A FAM214B FAM83A FAM90A1 FANCM FARS2 FASTKD5 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GADD45GIP1 GAS2L2 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNE GNPDA2 GPANK1 GPKOW GRB14 GRB2 GSE1 GTF2F1 HAPLN2 HAUS1 HCK HDAC1 HDAC4 HGS HIP1R HNRNPLL HOXB5 HOXB9 HOXC8 HR IGFN1 IKBKB IKBKE IL16 ILF2 ILK INO80B INPP5J IP6K3 IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 KRT3 KRT75 KRT76 LAGE3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMNB2 LMO1 LMO4 LNX1 LONRF1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAGOHB MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MSRB1 MTMR6 MVP MYO15B NCK2 NCOA1 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OTUB2 P2RX7 PIAS1 PIAS2 PIAS3 PIAS4 PIBF1 PIMREG PIN1 PKN1 PLEKHN1 PML POLE2 POLR1C POLR3C POM121 PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L QARS1 RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RIN1 RNF213 RNF25 RNF6 RSPH14 RXRB SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SMARCB1 SMARCD1 SMG9 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 STK26 SYNGAP1 SYT17 SYT6 TACO1 TBC1D22B TBK1 TCEA2 TCEANC TCHP TEAD4 TEX33 THOC1 TLE5 TMSB4X TMSB4XP6 TNS4 TP53 TPM3 TPRKB TRAF4 TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM50 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBASH3A UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP14C UTP23 VEZF1 VPS25 VPS28 VPS9D1 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFHX3 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF414 ZNF417 ZNF446 ZNF572 ZNF580 ZNF581 ZNF587 ZNF688 ZNF79	169 interacting genes: ABCD3 ABI2 ABI3 ACTN1 ACTN2 AGR2 APIP APP BANF2 BLZF1 C11orf49 C22orf39 CABP5 CALCOCO2 CBS CCDC102B CCDC136 CCDC153 CCDC85B CCNH CDA CDKN2D CDR2 CEP70 CEP72 CFAP206 CHMP1A CINP COG4 COG6 COIL CRX DCTD DCTPP1 DDIT4L DEF6 DLEU1 DYDC1 DYNLT1 EHMT2 EIF4A3 EMSY ERBB2 FNDC11 GNPTAB GOLGA2 GOLGA6A GPHN GSDMD GUCD1 HEXIM2 HOMER3 HOMEZ HOOK2 HOXC11 HSD17B14 HSF2BP IFT20 IKZF1 IKZF3 INO80E IPO13 KAZN KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS3 KRT13 KRT15 KRT19 KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP4-1 KRTAP5-9 KRTAP6-3 LDB1 LDOC1 LMO2 LONRF1 LZTFL1 LZTS1 LZTS2 MAD1L1 MAPK1 MAPRE1 MAPRE3 MCM6 MID2 MIEF1 MKNK2 MKRN3 MLH1 MRFAP1L1 MSANTD4 MT-CO2 MTUS2 NAB2 NBPF19 NECAB2 NME7 NMI NOP53 NOTCH2NLA PCBD1 PCYT2 PICK1 PLK1 PM20D2 PNMA1 PNMA2 PNMA5 POLR1C POMP PPCDC PRDM14 PRIMPOL PRKN PRPH PSMA2 PSMA3 PSMA4 PSMA7 PSMB1 PSMB10 PSMB2 PSMB5 RAD54B RBCK1 REL RFC2 RGS19 ROPN1 SAT1 SFMBT1 SH3BP4 SH3GLB1 SLF2 SPDEF SSX2IP TCF12 TCF4 TDO2 TEKT4 TNFAIP1 TNR TRAF1 TRAF5 TRIM10 TRIM23 TRIM27 TRIM42 TRIM54 TSC22D4 UBXN11 VCP VIM VMAC WTAP YPEL5 ZFAND1 ZMYND19
Entrez ID		5987	5682
HPRD ID		15996	04170
Ensembl ID		ENSG00000204713	ENSG00000129084
Uniprot IDs		A0A1U9X8R9 P14373	B4E0X6 P25786
PDB IDs			4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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