TRIM27 and IKBKB

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TRIM27	IKBKB
Description		tripartite motif containing 27	inhibitor of nuclear factor kappa B kinase subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Negative Regulation Of Adaptive Immune Response Negative Regulation Of Protein Kinase Activity Spermatogenesis Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Calcium Ion Import	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs			Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 32296059 31619474 29273806) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Childhood and early adolescence aggressive behavior ( 26087016) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate in diabetes ( 31451708) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Hemoglobin levels ( 32327693) Lung cancer in ever smokers ( 28604730) Neurociticism ( 29500382) Platelet aggregation ( 20526338) Pre-treatment viral load in HIV-1 infection ( 31219150) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Social communication problems ( 24047820) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		354 interacting genes: ABCA1 ABCF3 ABHD17A ACSF3 AEN AMMECR1 AMOTL2 AP1M1 ARHGEF3 ARHGEF5 ARID5A ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG3 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C1orf109 CAPN7 CARD10 CATSPER1 CBX8 CCDC102B CCDC185 CCDC187 CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDC7 CDK18 CDKL3 CFAP206 CHCHD3 CHD4 CHUK CKS1B CLK2 CNNM3 COX5B CPNE2 CPNE7 CREB5 CSRP2 CWF19L2 DBF4B DCX DDX6 DGCR6 DMRT3 DNMT1 DTNB DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4A3 EIF4E EIF4E2 ENKD1 EPC1 ERCC3 EXOC8 FAM110A FAM126A FAM126B FAM161A FAM193B FAM214A FAM214B FAM83A FAM90A1 FANCM FARS2 FASTKD5 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GADD45GIP1 GAS2L2 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNE GNPDA2 GPANK1 GPKOW GRB14 GRB2 GSE1 GTF2F1 HAPLN2 HAUS1 HCK HDAC1 HDAC4 HGS HIP1R HNRNPLL HOXB5 HOXB9 HOXC8 HR IGFN1 IKBKB IKBKE IL16 ILF2 ILK INO80B INPP5J IP6K3 IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 KRT3 KRT75 KRT76 LAGE3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMNB2 LMO1 LMO4 LNX1 LONRF1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAGOHB MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MSRB1 MTMR6 MVP MYO15B NCK2 NCOA1 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OTUB2 P2RX7 PIAS1 PIAS2 PIAS3 PIAS4 PIBF1 PIMREG PIN1 PKN1 PLEKHN1 PML POLE2 POLR1C POLR3C POM121 PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF18 PRPF31 PRR35 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L QARS1 RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RIN1 RNF213 RNF25 RNF6 RSPH14 RXRB SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SMARCB1 SMARCD1 SMG9 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 STK26 SYNGAP1 SYT17 SYT6 TACO1 TBC1D22B TBK1 TCEA2 TCEANC TCHP TEAD4 TEX33 THOC1 TLE5 TMSB4X TMSB4XP6 TNS4 TP53 TPM3 TPRKB TRAF4 TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM50 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBASH3A UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP14C UTP23 VEZF1 VPS25 VPS28 VPS9D1 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFHX3 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF414 ZNF417 ZNF446 ZNF572 ZNF580 ZNF581 ZNF587 ZNF688 ZNF79	87 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		5987	3551
HPRD ID		15996	04462
Ensembl ID		ENSG00000204713	ENSG00000104365
Uniprot IDs		A0A1U9X8R9 P14373	O14920
PDB IDs			3BRT 3BRV 4E3C 4KIK
Enriched GO Terms of Interacting Partners?
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