RAB3A and ADRB2

Data Source:
BioGRID (protein complementation assay)

		RAB3A	ADRB2
Description		RAB3A, member RAS oncogene family	adrenoceptor beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Axon Secretory Granule Membrane Protein-containing Complex Terminal Bouton Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane Extracellular Vesicle	Nucleus Lysosome Endosome Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Receptor Complex
	Molecular Function	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding GTP-dependent Protein Binding Myosin V Binding GDP-dissociation Inhibitor Binding ATPase Binding	Amyloid-beta Binding G Protein-coupled Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Norepinephrine Binding
	Biological Process	Plasma Membrane Repair Respiratory System Process Exocytosis Vesicle Docking Involved In Exocytosis Mitochondrion Organization Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axonogenesis Protein Secretion Post-embryonic Development Regulation Of Synaptic Vesicle Priming Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Regulation Of Exocytosis Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Positive Regulation Of ATPase Activity Synaptic Vesicle Recycling Neutrophil Degranulation Post-translational Protein Modification Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Protein Localization To Plasma Membrane Synaptic Vesicle Clustering Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair Regulation Of Synaptic Vesicle Exocytosis	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Endosome To Lysosome Transport Response To Cold Positive Regulation Of Protein Kinase A Signaling Protein Deubiquitination Positive Regulation Of Bone Mineralization Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Membrane Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production
Drugs			Spermine Amphetamine Betaxolol Bethanidine Isoetharine Cabergoline Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol Bedoradrine NCX 950 Asenapine Droxidopa Bufuralol Protokylol (S)-carazolol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Arotinolol Doxofylline Racepinephrine Dihydroergocornine DL-Methylephedrine Etafedrine Tulobuterol Levosalbutamol Dihydroergocristine
Diseases			Asthma
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Chronic obstructive pulmonary disease ( 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		29 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SYTL4 SYTL5 VRTN	160 interacting genes: ABCA7 ADGRG1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 ARV1 ATP6V0B ATP6V0D1 BACE1 BAZ2A BSG CAV3 CCKBR CCND2 CD4 CD68 CD81 CD9 CEACAM1 CENPB CLASP2 CLPTM1L CNN1 CRYM CSK DCAF10 DCLRE1A DNAJC14 DRD4 EGLN3 EIF2B1 FBXO17 GBP5 GJC2 GMPR2 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GOLGB1 GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GTF2B HDAC6 HNRNPK HS2ST1 HTR4 IL1B IL6R INSR KCNE1 KCNJ5 KCNJ6 KCNJ9 KCTD13 KLC1 LRATD2 MAPK8IP2 MBOAT2 MBP MCAM MDM2 MFSD12 MFSD2A MGLL MITF MOG MSR1 NAT14 NCOR2 NEDD4 NIPAL2 NOS1 NPTX1 OBP2A OPRD1 PLA2G2D PRDX1 PRKCD PRNP PTGDS PTGER1 PTGES2 RAB14 RAB27A RAB3A RACK1 RAN RAP2C REL RGR RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RIOX1 RNF41 RTN1 SACS SENP3 SI SLC37A1 SLC39A4 SLC52A2 SLC9A3R1 SLC9A3R2 SNCA SNCG SPTBN2 SRC STAT3 STAT4 TCTA TMCC2 TMEM144 TMEM187 TMEM259 TPTE TSG101 TSHR TSPAN7 UCHL1 UST VAPA VDAC1 VDAC2 VEGFB WNK1 YIPF5 YWHAQ ZNF25 ZNF254
Entrez ID		5864	154
HPRD ID		01535	00187
Ensembl ID		ENSG00000105649	ENSG00000169252
Uniprot IDs		A0A024R7I7 P20336	P07550 X5DQM5
PDB IDs			1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6KR8 6MXT 6N48 6NI3 6OBA 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6 7BZ2
Enriched GO Terms of Interacting Partners?
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