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BARD1 and CHD3
Data Source:
BioGRID
(pull down, two hybrid)
BARD1
CHD3
Description
BRCA1 associated RING domain 1
chromodomain helicase DNA binding protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
NuRD Complex
PML Body
Centriolar Satellite
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
ATPase Activity
Double-stranded DNA Helicase Activity
Nucleosome-dependent ATPase Activity
Biological Process
DNA Double-strand Break Processing
Tissue Homeostasis
DNA Replication
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Protein Deubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Assembly Or Disassembly
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Spindle Organization
Centrosome Cycle
DNA Duplex Unwinding
ATP-dependent Chromatin Remodeling
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Ischemic stroke (
26089329
)
Macular thickness (
30535121
)
Prostate cancer (
29892016
)
Refractive error (
32231278
)
Stroke (
26089329
)
Interacting Genes
125 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AX
H2BC21
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
96 interacting genes:
ACTR1B
ADH5
AIMP2
ATP5IF1
BARD1
BCL6
BHLHE40
C4orf17
CASP6
CASP8
CPE
CRCT1
CREB1
CREBBP
CSTF2
CTBP1
CTTN
ENTR1
FABP4
FBP2
FUBP1
GADD45A
GIT1
GPS2
GSK3B
H3C1
HABP4
HSD17B10
HSPH1
HTT
IK
IKZF1
IKZF3
IMMT
IVNS1ABP
KIF15
KPNA2
KPNB1
LRIF1
LUC7L2
MAFG
MAN2A2
MX1
MYB
NEFL
NR1H2
NR4A1
PAICS
PCMT1
PIAS4
PLK4
PRG2
PRPF40A
PSME1
PTN
PTPRS
PUF60
RAD51
RETREG2
RGS2
RIF1
RPL29
SAFB
SAT1
SATB1
SERBP1
SERF2
SGSM2
SIRT6
SKIL
SLC27A6
SPOP
SRRT
SUMO1
SUMO2
TAL1
TCERG1
THOC7
TNFRSF14
TNNT1
TP53
TP73
TRIM28
TRIM54
TSC22D1
TSPAN6
TTR
TXNDC9
UBA3
UBC
UBE2I
UROD
VIM
XRCC4
YAE1
ZHX1
Entrez ID
580
1107
HPRD ID
03354
09071
Ensembl ID
ENSG00000138376
ENSG00000170004
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
B3KWV4
Q12873
Q2TAZ1
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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