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BAK1 and BCL2L2
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
BAK1
BCL2L2
Description
BCL2 antagonist/killer 1
BCL2 like 2
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Integral Component Of Mitochondrial Outer Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Mitochondrial Outer Membrane
Bcl-2 Family Protein Complex
Molecular Function
Molecular_function
Protein Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Chaperone Binding
BH Domain Binding
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Disordered Domain Specific Binding
Biological Process
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Brain Development
Aging
Mitochondrial Fusion
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Response To Organic Cyclic Compound
Viral Process
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Negative Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Drugs
Navitoclax
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
28165464
22700719
24292274
23770605
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
26805783
22139419
24026423
29066854
23263863
29403010
32888494
22423221
25705162
20139978
27863252
28031487
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Schizophrenia (
30285260
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
19483681
28604728
28604732
23666239
23666240
)
Height (
28552196
)
Interacting Genes
19 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
VDAC1
VDAC2
53 interacting genes:
ANKS6
APOC1
APOC2
APOC4
ATP5PF
BAD
BAK1
BAX
BBC3
BCL2L11
BHLHA9
BID
BIK
BMF
BNIP3
BNIP5
C10orf67
CD79A
CHODL
CIDEB
CISD2
CLDN7
ERVFRD-1
FATE1
G0S2
GORAB
GPR151
GPX8
HRK
KASH5
KCNJ6
LMNA
LRRIQ1
MGST2
MUC1
PANX1
PPP1CA
PSCA
RHBDD2
S100B
SAR1A
SGPL1
SLC35C2
SLC35E3
SLC39A2
SLC39A6
STOM
SUSD3
TCF4
TEX11
TMEM139
TMX1
TP53
Entrez ID
578
599
HPRD ID
02744
03569
Ensembl ID
ENSG00000030110
ENSG00000129473
Uniprot IDs
A0A0S2Z391
Q16611
Q92843
PDB IDs
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
1MK3
1O0L
1ZY3
2Y6W
4CIM
Enriched GO Terms of Interacting Partners
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