BCL2L2 and BAX

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		BCL2L2	BAX
Description		BCL2 like 2	BCL2 associated X, apoptosis regulator
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Bcl-2 Family Protein Complex	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Pore Complex Extracellular Exosome Cell Periphery Bcl-2 Family Protein Complex BAX Complex BAK Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Disordered Domain Specific Binding	Protein Binding Lipid Binding Channel Activity Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Chaperone Binding BH3 Domain Binding
	Biological Process	Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Neuron Migration T Cell Homeostatic Proliferation B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection B Cell Homeostatic Proliferation Positive Regulation Of B Cell Apoptotic Process Transcription Initiation From RNA Polymerase II Promoter Glycosphingolipid Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Germ Cell Development Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Apoptotic Mitochondrial Changes Fertilization Response To Toxic Substance Response To Salt Stress Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Negative Regulation Of Mitochondrial Membrane Potential Viral Process Hypothalamus Development Cerebral Cortex Development Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Release Of Matrix Enzymes From Mitochondria Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Unfolded Protein Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Development Of Secondary Sexual Characteristics Retinal Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation Negative Regulation Of Fibroblast Proliferation Spermatid Differentiation Post-embryonic Camera-type Eye Morphogenesis Response To Axon Injury Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Potential Sertoli Cell Proliferation Retina Development In Camera-type Eye Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Mitochondrion Morphogenesis Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Blood Vessel Morphogenesis Apoptotic Process Involved In Embryonic Digit Morphogenesis Regulation Of Mitochondrial Membrane Permeability Involved In Programmed Necrotic Cell Death Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of IRE1-mediated Unfolded Protein Response B Cell Receptor Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor
Drugs		Navitoclax
Diseases			Colorectal cancer
GWAS		Height ( 28552196)	Asthma ( 27611488) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	30 interacting genes: ANP32B BAK1 BBC3 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L12 BCL2L2 BID ERN1 HSF2BP KCNA3 LEF1 MAP2K1 MCL1 MOAP1 NOL3 PARK7 PMAIP1 PPP1CA SFN SH3GLB1 SLC25A4 TP53 UHRF2 VDAC1 YWHAB YWHAQ ZBTB24
Entrez ID		599	581
HPRD ID		03569	02498
Ensembl ID		ENSG00000129473	ENSG00000087088
Uniprot IDs		Q92843	I6LPK7 Q07812 Q5ZPJ0 Q5ZPJ1
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	1F16 2G5B 2K7W 2LR1 3PK1 3PL7 4BD2 4BD6 4BD7 4BD8 4BDU 4S0O 4S0P 4UF2 4ZIE 4ZIF 4ZIG 4ZIH 4ZII 5W5X 5W5Z 5W60 5W61 6EB6 6TRR 6XY6
Enriched GO Terms of Interacting Partners?
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