Wiki-Pi
About
Search
Browse
People
Updates
Search
PSMC6 and SDCBP
Data Source:
BioGRID
(two hybrid, two hybrid)
PSMC6
SDCBP
Description
proteasome 26S subunit, ATPase 6
syndecan binding protein
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Cytosolic Proteasome Complex
Extracellular Exosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Interleukin-5 Receptor Complex
Adherens Junction
Focal Adhesion
Membrane
Nuclear Membrane
Azurophil Granule Lumen
Melanosome
Membrane Raft
Synapse
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Protein Binding
ATP Binding
ATPase Activity
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Frizzled Binding
Interleukin-5 Receptor Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Anchor Activity
Identical Protein Binding
Syndecan Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Ubiquitin-dependent ERAD Pathway
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Receptor Internalization
Protein Targeting To Membrane
Substrate-dependent Cell Migration, Cell Extension
Chemical Synaptic Transmission
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Actin Cytoskeleton Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intracellular Signal Transduction
Positive Regulation Of Phosphorylation
Neutrophil Degranulation
Positive Regulation Of JNK Cascade
Ephrin Receptor Signaling Pathway
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Ephrin signaling
Neurofascin interactions
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
Neutrophil degranulation
Drugs
Diseases
GWAS
Prostate cancer (
23535732
)
Low density lipoprotein cholesterol levels (
32154731
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Triglyceride levels (
32154731
)
Interacting Genes
24 interacting genes:
BYSL
C1orf216
CCDC146
CCDC85B
CCT2
CDC37
CDC42
CRK
CRKL
CYB5R2
GTF2A1
PAAF1
PSMA6
PSMC2
PSMC3
PSMC4
PSMC5
PSMD13
PSMD9
SDCBP
SEC14L5
SMARCE1
UBC
UBE2I
307 interacting genes:
ABI2
ANKRD33
ANKRD36B
ANKRD40
ANP32B
APIP
ARFIP2
ARL6IP1
BCL2L15
BEND7
C11orf68
C1orf109
C1orf35
C2CD2L
CABP5
CADM1
CADPS
CALCOCO2
CALM1
CALM2
CALM3
CAV2
CBR3
CBY2
CCDC102B
CCDC106
CD6
CD63
CDA
CDC34
CDCP1
CDIPT
CDKN2D
CEP55
CEP85
CGGBP1
CHIC2
CHMP1A
CLK2
CLK3
CMTM5
COX4I1
CRX
CRYAA
CRYAA2
CT45A1
CT45A10
CT45A3
CT45A5
CTBP2
CTDSP1
CUTC
CYHR1
DCTD
DCTPP1
DDX39B
DERL3
DMC1
DNM2
DRAP1
DTNBP1
DYNLT1
EAF1
EDARADD
EFNB1
EFNB2
EIF1AD
EIF5A
EIF5A2
ELAVL1
EMILIN3
ENOX1
ENTR1
EPHB2
ERICH2
EXOSC4
FADD
FAM118A
FAM118B
FAM9A
FAM9B
FHL3
FHL5
FLAD1
FOXP2
FTH1
FTL
GET4
GGPS1
GKAP1
GNMT
GOLT1B
GPATCH11
GPR37
GRIA1
GRIA2
GRIA3
GRIA4
GRIK1
GRIK2
GRM2
GRM3
GRM7
GRXCR1
GSC2
GSG1
HEXIM2
HHAT
HIVEP1
HMBOX1
HMGB3
HNRNPC
HOMER3
HOMEZ
HOXA1
HOXA7
HPRT1
HSBP1
HSF2BP
HUS1
ID3
IGFBP6
IHO1
IKZF1
IL5RA
INO80E
KATNBL1
KCNH1
KCNJ2
KCTD1
KCTD6
KCTD9
KHDRBS2
KLHL12
KLHL2
KRT14
KRTAP1-3
KRTAP1-5
KRTAP10-3
KRTAP10-7
KRTAP5-9
LDB2
LDHB
LDOC1
LEPROTL1
LGALS2
LSM6
LURAP1L
LZTFL1
MAD2L1
MAPK9
MAPRE3
MATN4
MBD3
MED4
MEOX1
MEOX2
MGLL
MID2
MINDY3
MKRN1
MOBP
MRFAP1
MRFAP1L1
MTUS2
MYBPC2
MYLIP
N4BP3
NADK
NAGK
NAPB
NECAB2
NF2
NFASC
NKAPD1
NOTCH2NLA
NT5C2
OCM
ODAM
OPTN
OSTF1
PCBD1
PCYT1A
PDCD6IP
PDE4DIP
PDE9A
PDLIM4
PDZK1IP1
PFDN5
PHC2
PHF11
PIH1D2
PNMA1
PNMA2
POLR2J
POLR3K
PPARA
PRPF38A
PRPF40A
PRR13
PSMB3
PSMC6
PSME2
PSTPIP1
PTEN
PTPRJ
PTS
PUF60
PYCR3
RAB5A
RALY
RBM39
REEP6
REL
RIC8A
RNF11
RNH1
ROPN1
RP9
RP9P
RPIA
RPL22
RPRD1A
RPRM
RPS26
RRM2
RRS1
RTL8B
RTN1
RUNDC3A
S100B
SCG3
SCML1
SDC1
SDC2
SDC4
SDCBP2
SEPTIN1
SEPTIN3
SET
SFT2D1
SIAH1
SLC50A1
SLC6A5
SMARCA2
SNRPA
SNX1
SOX4
SPANXN3
SREK1IP1
SRSF11
SRSF3
SRSF7
SSC5D
SSNA1
STX1A
SUB1
SULT1B1
SYNGR1
SYPL1
SYS1
TCF21
TCF4
TDO2
TEKT1
TFCP2
TGFA
THG1L
TIFA
TKFC
TLE5
TMCO2
TMEM17
TMEM239
TNFAIP8
TNFAIP8L3
TNKS
TRAF5
TRARG1
TRIM27
TRIM32
TRIM38
TRIM54
TRIP13
TSN
UBB
UBC
UBE2A
UBE2K
UBE2R2
ULK1
WASHC1
WASHC3
WASL
WDR91
YIF1A
ZBTB14
ZBTB8A
ZCCHC10
ZCCHC17
ZMYND12
ZNF343
ZNF485
ZNF660
ZNF768
ZRANB1
ZSCAN23
Entrez ID
5706
6386
HPRD ID
04086
03741
Ensembl ID
ENSG00000100519
ENSG00000137575
Uniprot IDs
A0A087X2I1
P62333
A0A024R7Z5
B4DHN5
G5EA09
O00560
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
1N99
1NTE
1OBX
1OBY
1OBZ
1R6J
1V1T
1W9E
1W9O
1W9Q
1YBO
4Z33
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?