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PSEN2 and ACTG1
Data Source:
BioGRID
(two hybrid)
PSEN2
ACTG1
Description
presenilin 2
actin gamma 1
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Kinetochore
Nucleus
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Growth Cone
Neuromuscular Junction
Protein-containing Complex
Ciliary Rootlet
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Apical Junction Complex
Extracellular Exosome
Blood Microparticle
Dense Body
Molecular Function
Endopeptidase Activity
Protein Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Structural Constituent Of Cytoskeleton
Protein Binding
Profilin Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Biological Process
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Ephrin Receptor Signaling Pathway
Amyloid-beta Metabolic Process
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Angiogenesis
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Cell Junction Assembly
Maintenance Of Blood-brain Barrier
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Ephrin Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Membrane Organization
Platelet Aggregation
Positive Regulation Of Wound Healing
Postsynaptic Actin Cytoskeleton Organization
Tight Junction Assembly
Regulation Of Transepithelial Transport
Protein Localization To Bicellular Tight Junction
Pathways
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
Copper
Artenimol
Diseases
Alzheimer's disease (AD)
GWAS
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Hand grip strength (
29313844
)
Refractive error (
32231278
)
Interacting Genes
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
68 interacting genes:
ABLIM1
ACTB
ANXA5
ATF7IP
BCAP31
BIN1
BRCA1
CAP1
CAP2
CAPZA3
CCDC22
CDC37
CDKN2A
CFL1
CFL2
COTL1
CTBP2
CTTN
CYBB
DISC1
DNASE1
DSTN
DUX4
DYNLL1
EHHADH
EIF6
FHOD1
FPR1
GIT2
GSN
GZMA
GZMK
HRAS
HSPB2
LGALS13
LIG4
LINC01554
LSP1
MAP1A
MAPK6
MAPT
MCPH1
MYO1A
MYOC
NDRG1
NR3C2
NTAQ1
PFN2
PLD1
PLEC
PPP1R9A
PRSS23
PSEN2
PTPRO
RPS6KA5
SCIN
SH3GL2
SRPK2
ST3GAL3
SUMO4
TMSB4X
TMSB4Y
TNIK
VASP
VIL1
WASF1
WASL
WIPF1
Entrez ID
5664
71
HPRD ID
02860
00017
Ensembl ID
ENSG00000143801
ENSG00000184009
Uniprot IDs
P49810
P63261
PDB IDs
5JLH
6CXI
6CXJ
6G2T
6V62
6V63
6WK1
6WK2
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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