PSEN2 and DOCK3

Data Source:
HPRD (in vitro, two hybrid)

		PSEN2	DOCK3
Description		presenilin 2	dedicator of cytokinesis 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Kinetochore Nucleus Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Apical Plasma Membrane Z Disc Growth Cone Neuromuscular Junction Protein-containing Complex Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Gamma-secretase Complex	Cytosol
	Molecular Function	Endopeptidase Activity Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Ephrin Receptor Signaling Pathway Amyloid-beta Metabolic Process Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Small GTPase Mediated Signal Transduction Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Pathways		Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3	NTRK2 activates RAC1 NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Alzheimer's disease (AD)
GWAS		Heel bone mineral density ( 30598549) Refractive error ( 32231278)	Asthma ( 32296059) Bacteremia ( 27236921) Blood protein levels ( 28240269) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Colorectal cancer ( 29228715) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163) Height ( 20881960 25282103) Melanoma ( 24980573) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	10 interacting genes: CALM1 CRK HOXA1 KHDRBS1 NR3C1 PLEKHF2 PSEN1 PSEN2 RAC1 SRPK2
Entrez ID		5664	1795
HPRD ID		02860	10341
Ensembl ID		ENSG00000143801	ENSG00000088538
Uniprot IDs		P49810	Q8IZD9
PDB IDs
Enriched GO Terms of Interacting Partners?
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