MMP26 and IGFBP1

Data Source:
HPRD (in vivo, in vitro)

		MMP26	IGFBP1
Description		matrix metallopeptidase 26	insulin like growth factor binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus
	Molecular Function	Metalloendopeptidase Activity Zinc Ion Binding	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Inflammatory Response	Signal Transduction Aging Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth PERK-mediated Unfolded Protein Response Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Marimastat
Diseases
GWAS		Coenzyme Q10 levels ( 27149984) Malaria ( 31844061) Mean corpuscular volume ( 28453575)	Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)
Interacting Genes		4 interacting genes: ERRFI1 IGFBP1 MMP9 SERPINA1	4 interacting genes: IGF1 IGF2 MMP26 TF
Entrez ID		56547	3484
HPRD ID		05683	00897
Ensembl ID		ENSG00000167346	ENSG00000146678
Uniprot IDs		Q9NRE1	P08833
PDB IDs			1ZT3 1ZT5 2DSQ
Enriched GO Terms of Interacting Partners?
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