IGFBP1 and IGF1

Data Source:
HPRD (in vitro)

		IGFBP1	IGF1
Description		insulin like growth factor binding protein 1	insulin like growth factor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex Platelet Alpha Granule Lumen Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin-like Growth Factor Ternary Complex Exocytic Vesicle
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity
	Biological Process	Signal Transduction Aging Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth PERK-mediated Unfolded Protein Response Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway	Activation Of MAPK Activity Skeletal System Development Cell Activation Platelet Degranulation Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Heat Glycolate Metabolic Process Regulation Of Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Proteoglycan Biosynthetic Process Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Smooth Muscle Cell Apoptotic Process Bone Mineralization Involved In Bone Maturation Regulation Of Multicellular Organism Growth Wound Healing Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Protein Kinase B Signaling Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Myoblast Proliferation Negative Regulation Of Oocyte Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Trophectodermal Cell Proliferation Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin
Drugs			N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases			Malignant pleural mesothelioma Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Major depressive disorder ( 23377640) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 28135244 30487518) Rheumatoid arthritis ( 21156761) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27618447)	Birth weight ( 31043758 27680694) Brain morphology (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Fasting blood insulin ( 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) FEV1 ( 30804560) Height ( 25429064 19893584 31562340 31217584 20189936) Homeostasis model assessment of insulin resistance ( 20081858) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Lung function (FVC) ( 30804560) Mammographic density (dense area) ( 25342443) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Response to quetiapine in schizophrenia ( 29503163) Systolic blood pressure ( 30224653) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: IGF1 IGF2 MMP26 TF	22 interacting genes: BANP CCN3 CCN5 CTSB E2F1 ENKD1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 MESD MKRN3 SOX4 TCEANC TF
Entrez ID		3484	3479
HPRD ID		00897	00936
Ensembl ID		ENSG00000146678	ENSG00000017427
Uniprot IDs		P08833	P05019 Q13429 Q59GC5 Q5U743
PDB IDs		1ZT3 1ZT5 2DSQ	1B9G 1BQT 1GF1 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI 4XSS 5U8Q 6FF3 6PYH 6RVA
Enriched GO Terms of Interacting Partners?
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