PRPH and FCHO1

Data Source:
BioGRID (two hybrid)

		PRPH	FCHO1
Description		peripherin	FCH and mu domain containing endocytic adaptor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Intermediate Filament Membrane Axon Perikaryon Type III Intermediate Filament Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding AP-2 Adaptor Complex Binding
	Biological Process	Intermediate Filament Cytoskeleton Organization	Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)	Basophil count ( 32888494) Coronary artery disease ( 29212778) Monocyte percentage of white cells ( 32888494)
Interacting Genes		36 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT19 KRT20 KRT24 KRT27 KRT31 KRT75 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572	51 interacting genes: ACVR1 APP BYSL CCDC13 CSNK2A1 CWF19L2 DAB2 DDX6 DNAJC5 ELOA EPS15 EPS15L1 EXOSC5 FBXL7 GRB7 GUCD1 ITSN1 KAT5 KPRP KRTAP10-1 KRTAP10-5 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP4-12 KRTAP6-1 KRTAP6-3 LGALS14 MAB21L3 NCK1 PCGF1 PHETA1 PHLDA2 PICALM PLAC8 PLSCR4 PRPF3 PRPH PTK6 SH2D4A SMURF1 SRPK2 SYTL4 TCEA2 TCEANC TGFB1 TRIM42 TSPAN4 ZBTB16 ZBTB24 ZNF688
Entrez ID		5630	23149
HPRD ID		01365	16887
Ensembl ID		ENSG00000135406	ENSG00000130475
Uniprot IDs		B3KWQ6 P41219	A0A0C3SFZ9 B7ZAZ3 O14526
PDB IDs
Enriched GO Terms of Interacting Partners?
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