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ERBIN and LMO2
Data Source:
BioGRID
(two hybrid)
ERBIN
LMO2
Description
erbb2 interacting protein
LIM domain only 2
Image
GO Annotations
Cellular Component
Basement Membrane
Nucleus
Cytoplasm
Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Nuclear Speck
Cell Junction
Hemidesmosome
Nuclear Membrane
Postsynapse
Glutamatergic Synapse
Nucleoplasm
Transcription Regulator Complex
Molecular Function
Signaling Receptor Binding
ErbB-2 Class Receptor Binding
Structural Constituent Of Cytoskeleton
Protein Binding
RNA Polymerase II Activating Transcription Factor Binding
Transcription Coregulator Binding
Transcription Coactivator Activity
Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Biological Process
Protein Targeting
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
ERBB2 Signaling Pathway
Intermediate Filament Cytoskeleton Organization
Basal Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Multicellular Organism Development
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Thyroid Hormone Stimulus
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Signaling by ERBB2
Downregulation of ERBB2 signaling
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Cognitive performance (
19734545
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Iron status biomarkers (transferrin saturation) (
28334935
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Interacting Genes
66 interacting genes:
ABCA1
ABCC4
ABR
ACTN1
ACTN2
ACVR2A
ACVR2B
AGTR2
APC
ARHGEF7
ARVCF
ATP2B1
ATP2B2
ATP2B4
BANF1
CASK
CDH1
CHUK
COPB1
CTNNB1
CTNND1
CTNND2
CTSG
DLG4
DST
ERBB2
FOXO3
GRIN2B
GRIN2C
GUCY1A2
ITGB4
KCNA4
KCNA5
LAMB1
LMO1
LMO2
LRRC1
MAP4
MAPK12
MCC
MEF2A
MPP1
MPP2
MPP3
MUSK
NOD2
NR2E1
PICK1
PKP4
RAF1
RBX1
RNF7
RPS6KA1
SCN4A
SHOC2
SLC5A5
SLC5A6
SLC6A12
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
STAT3
VIPR2
ZFYVE9
188 interacting genes:
ABI2
ADAMTSL4
AFDN
AGTRAP
AIMP2
ALDH6A1
ARHGEF5
ARID5A
ARNT2
AXIN1
BANP
BCAS2
BEX2
BLZF1
BYSL
C1orf109
C1orf94
CALCOCO2
CBY2
CCDC33
CDC25A
CDC5L
CDX4
CLHC1
CMTM5
CORO1A
CORO1C
DAZAP2
DBF4B
DDIT3
DMRT3
DRAP1
DYDC1
EFHC1
EFHC2
EHMT2
EIF3B
EIF4EBP1
ELF2
ENKD1
ERBIN
FAAP20
FAM214B
FAM228A
FAM90A1
FHL3
FHL5
GAS8
GATA1
GATA2
GATA3
GFAP
GMEB2
GOLGA2
GRB2
HDAC5
HNRNPC
HNRNPM
HOOK1
ICA1L
IFT43
IHO1
IKZF1
IKZF3
INCA1
ISL1
ISY1
KANK2
KAZN
KDM5A
KIF2A
KIF3B
KPRP
KRT15
KRT34
KRT40
KRT75
KRT80
KRTAP10-7
LDB1
LDB2
LDOC1
LMO4
LMOD3
LYL1
LZTS1
LZTS2
MAGEA8
MAPRE1
MAPRE2
MAPRE3
MBIP
MISP
MRFAP1L1
MSN
MTUS2
MYOZ3
N4BP2L2
NCAPH2
NDOR1
NDUFAB1
NDUFB7
NFKBID
NHLH1
NIF3L1
NOTCH2NLA
NOXA1
NSMF
NTAQ1
NUP62
NUTM1
PATZ1
PAX9
PBX4
PDE9A
PHC2
POLR2G
PPP1R32
PRDM6
PRKG1
PSMA1
RBBP8
RCN1
REL
RELA
RINT1
RLIM
ROCK1
RTL8C
RUSC1
SAXO1
SGTB
SKP1
SMAD2
SMUG1
SNAPC5
SOX5
SP1
SSX2IP
STAT1
STAT3
STIP1
TAL1
TAL2
TBX2
TCP10L
TEKT3
TFIP11
TFPT
THAP6
TLE5
TLX3
TRIB3
TRIM23
TRIM54
TRIM55
TRIM63
TRIP6
TSC1
TSC22D4
TSEN15
TSEN54
TSGA10IP
TSPYL2
TSSK3
TUFT1
UBA6
UBASH3B
UBE2I
USH1G
VBP1
VEZF1
VMAC
WASF1
WASHC1
YOD1
YPEL3
ZFP64
ZMYND12
ZNF185
ZNF19
ZNF24
ZNF250
ZNF34
ZNF410
ZNF641
ZNF655
ZNF688
Entrez ID
55914
4005
HPRD ID
06090
01586
Ensembl ID
ENSG00000112851
ENSG00000135363
Uniprot IDs
Q96RT1
P25791
PDB IDs
1MFG
1MFL
1N7T
2H3L
2QBW
3CH8
6Q0M
6Q0N
6Q0U
6UBG
6UBH
2XJY
2XJZ
2YPA
4KFZ
Enriched GO Terms of Interacting Partners
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