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ERBIN and PKP4
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
ERBIN
PKP4
Description
erbb2 interacting protein
plakophilin 4
Image
No pdb structure
GO Annotations
Cellular Component
Basement Membrane
Nucleus
Cytoplasm
Plasma Membrane
Basal Plasma Membrane
Basolateral Plasma Membrane
Nuclear Speck
Cell Junction
Hemidesmosome
Nuclear Membrane
Postsynapse
Glutamatergic Synapse
Spindle Pole
Cornified Envelope
Nucleus
Cytoplasm
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Adherens Junction
Cytoplasmic Side Of Plasma Membrane
Cell Junction
Desmosome
Midbody
Cell-cell Contact Zone
Perinuclear Region Of Cytoplasm
Spindle Midzone
Mitotic Spindle
Molecular Function
Signaling Receptor Binding
ErbB-2 Class Receptor Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Protein Binding
Cadherin Binding
Biological Process
Protein Targeting
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
ERBB2 Signaling Pathway
Intermediate Filament Cytoskeleton Organization
Basal Protein Localization
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Cell-cell Junction Assembly
Cell-cell Signaling
Regulation Of Cell Adhesion
Keratinization
Positive Regulation Of Cytokinesis
Positive Regulation Of GTPase Activity
Cornification
Cell-cell Adhesion
Pathways
Signaling by ERBB2
Downregulation of ERBB2 signaling
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Keratinization
Formation of the cornified envelope
Drugs
Diseases
GWAS
Borderline personality disorder (
28632202
)
Obesity-related traits (
23251661
)
Restless legs syndrome (
29029846
)
Interacting Genes
66 interacting genes:
ABCA1
ABCC4
ABR
ACTN1
ACTN2
ACVR2A
ACVR2B
AGTR2
APC
ARHGEF7
ARVCF
ATP2B1
ATP2B2
ATP2B4
BANF1
CASK
CDH1
CHUK
COPB1
CTNNB1
CTNND1
CTNND2
CTSG
DLG4
DST
ERBB2
FOXO3
GRIN2B
GRIN2C
GUCY1A2
ITGB4
KCNA4
KCNA5
LAMB1
LMO1
LMO2
LRRC1
MAP4
MAPK12
MCC
MEF2A
MPP1
MPP2
MPP3
MUSK
NOD2
NR2E1
PICK1
PKP4
RAF1
RBX1
RNF7
RPS6KA1
SCN4A
SHOC2
SLC5A5
SLC5A6
SLC6A12
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
STAT3
VIPR2
ZFYVE9
19 interacting genes:
ATPAF2
CDH1
CDH2
CDH5
DSC3
DSP
ERBIN
GABARAP
GOLGA2
LNX1
LZTS2
MINK1
OSGEP
PAXIP1
PDZD2
PGAM1
PSEN1
TRIM23
UBASH3B
Entrez ID
55914
8502
HPRD ID
06090
05043
Ensembl ID
ENSG00000112851
ENSG00000144283
Uniprot IDs
Q96RT1
Q99569
PDB IDs
1MFG
1MFL
1N7T
2H3L
2QBW
3CH8
6Q0M
6Q0N
6Q0U
6UBG
6UBH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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