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PRKCA and SLC9A3R1
Data Source:
BioGRID
(pull down)
PRKCA
SLC9A3R1
Description
protein kinase C alpha
SLC9A3 regulator 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Mitochondrial Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Ruffle
Nucleus
Cytoplasm
Microvillus
Endomembrane System
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Filopodium
Brush Border Membrane
Microvillus Membrane
Vesicle
Stereocilium Tip
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Sperm Midpiece
Plasma Membrane Protein Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Integrin Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Enzyme Binding
Histone Kinase Activity (H3-T6 Specific)
Signaling Receptor Binding
Protein Binding
Beta-catenin Binding
Gamma-aminobutyric Acid Transmembrane Transporter Activity
Chloride Channel Regulator Activity
Phosphatase Binding
PDZ Domain Binding
Beta-2 Adrenergic Receptor Binding
Type 2 Metabotropic Glutamate Receptor Binding
Type 3 Metabotropic Glutamate Receptor Binding
Protein-membrane Adaptor Activity
Protein Self-association
Protein-containing Complex Binding
Myosin II Binding
Protein N-terminus Binding
Dopamine Receptor Binding
Growth Factor Receptor Binding
Biological Process
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Desmosome Assembly
Protein Phosphorylation
Mitotic Nuclear Envelope Disassembly
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Platelet Activation
Positive Regulation Of Cell Migration
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Histone H3-T6 Phosphorylation
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Bone Resorption
Positive Regulation Of Cell Adhesion
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Insulin Secretion
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Dense Core Granule Biogenesis
Morphogenesis Of An Epithelium
Renal Sodium Ion Transport
Plasma Membrane Organization
Nuclear Migration
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Cell Size
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Wnt Signaling Pathway
Gland Morphogenesis
Microvillus Assembly
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Cellular Phosphate Ion Homeostasis
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium:proton Antiporter Activity
Bile Acid Secretion
Glutathione Transport
Positive Regulation Of Ion Transmembrane Transport
Regulation Of Excretion
Cilium Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Protein Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Establishment Of Golgi Localization
Negative Regulation Of Protein Kinase B Signaling
Gamma-aminobutyric Acid Import
Auditory Receptor Cell Stereocilium Organization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Protein-containing Complex Assembly
Renal Absorption
Negative Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Plasma Membrane
Negative Regulation Of Canonical Wnt Signaling Pathway
Cerebrospinal Fluid Circulation
Renal Phosphate Ion Absorption
Import Across Plasma Membrane
Transport Across Blood-brain Barrier
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Inactivation, recovery and regulation of the phototransduction cascade
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Trafficking of GluR2-containing AMPA receptors
G alpha (z) signalling events
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
ROBO receptors bind AKAP5
Drugs
Phosphatidyl serine
Vitamin E
Tamoxifen
Ingenol mebutate
Aprinocarsen
Midostaurin
Perifosine
Ellagic acid
Bryostatin 1
alpha-Tocopherol succinate
D-alpha-Tocopherol acetate
Diseases
Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
28240269
)
Cardiorespiratory fitness (800m run time) (
32572135
)
Carotid intima media thickness x smoking interaction (
32117412
)
Coronary artery calcification (
23870195
)
Cryptosporidiosis (
32019797
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
32602732
)
Feeling guilty (
29500382
)
Food addiction (
27106561
)
Gout (
22179738
)
Height (
22021425
)
Heschl's gyrus morphology (
25130324
)
Lateral occipital cortex volume (
31530798
)
Neuroticism (
29255261
)
Percent glycated albumin (
29844224
)
Possible neuropathic pain in post total joint replacement surgery for osteoarthritis (
28051079
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
PR interval (
32439900
)
QRS complex (12-leadsum) (
27659466
)
QRS complex (Sokolow-Lyon) (
27659466
)
QRS duration (
27577874
30012220
27659466
)
QT interval (
29213071
24952745
29874175
)
Systolic blood pressure (
31170924
)
Total glycated albumin levels (
29844224
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Dental caries (decayed and filled deciduous tooth surfaces) (
31533690
)
Fibrinogen (
20031577
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
228 interacting genes:
ACTA1
ADAP1
ADCY5
ADD1
ADD3
ADRA1B
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CACYBP
CASR
CAVIN2
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EGLN2
EIF2S1
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FBXO7
FCGR2B
FCGR3A
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRK2
GRM1
GRM5
GSK3A
GSK3B
H1-1
H1-2
H1-3
H1-4
H1-5
H1-6
H3-4
H3C1
HABP4
HAND1
HAND2
HES1
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HR
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MAPKAP1
MAPT
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NF2
NFATC1
NFE2L2
NFKBIA
NOS1
NOXA1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PHB2
PICK1
PLA2G4A
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPM1A
PPP1R14A
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN11
PTPN12
PTPN6
RAC1
RACK1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SLC9A3R1
SLC9A3R2
SMURF1
SNAP23
SNAP25
SPAG1
SPP1
SRC
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
61 interacting genes:
ABCC2
ABCC4
ADRB2
AKAP10
AKT1
APPBP2
ATP6V1B1
ATP6V1E1
BCL10
BCL2A1
CFTR
CLCN3
CNGA2
CRABP1
CTNNB1
DLGAP4
EGFR
EZR
GNA11
GNAQ
GRK6
KCNJ1
LHCGR
LPAR2
MSN
NF2
NOS2
OPRK1
P2RY1
PAG1
PDGFRA
PDGFRB
PDZK1
PHLPP1
PLCB1
PLCB2
PRKCA
PTEN
PTH1R
RDX
RLBP1
SCN4A
SKP2
SLC13A1
SLC22A11
SLC22A4
SLC22A5
SLC22A9
SLC26A3
SLC34A1
SLC4A7
SLC4A8
SLC9A3
SLCO1A2
SLCO3A1
TBC1D10A
TRPC4
TRPC5
YAP1
YES1
ZNF468
Entrez ID
5578
9368
HPRD ID
01498
05406
Ensembl ID
ENSG00000154229
ENSG00000109062
Uniprot IDs
L7RSM7
P17252
Q7Z727
O14745
PDB IDs
2ELI
3IW4
4DNL
4RA4
1G9O
1GQ4
1GQ5
1I92
1SGH
2D10
2JXO
2KJD
2KRG
2M0T
2M0U
2M0V
2OZF
4JL7
4LMM
4MPA
4N6X
4PQW
4Q3H
6RQR
Enriched GO Terms of Interacting Partners
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