PRKCA and HLA-A

Data Source:
HPRD (in vitro, in vivo)

		PRKCA	HLA-A
Description		protein kinase C alpha	major histocompatibility complex, class I, A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Membrane Alphav-beta3 Integrin-PKCalpha Complex Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex MHC Class I Peptide Loading Complex Recycling Endosome Membrane Extracellular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)	RNA Binding Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding CD8 Receptor Binding TAP Binding TAP Complex Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis	T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-dependent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of T Cell Cytokine Production Immune Response Viral Process Detection Of Bacterium Protein Ubiquitination Antibacterial Humoral Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Interferon-gamma Production CD8-positive, Alpha-beta T Cell Activation Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Immune Response Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Memory T Cell Activation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Phosphatidyl serine Vitamin E Tamoxifen Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate	3-Indolebutyric Acid Nelipepimut-S Nelipepimut-S Coccidioides immitis spherule Coccidioides immitis spherule
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 30012220 27659466) QT interval ( 29213071 24952745 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)	Adult body size ( 32376654) Adverse response to carbamazepine ( 21149285) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) C-peptide levels in type I diabetes ( 29404672) Carbamazepine-induced maculopapular exanthema ( 29288229) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Childhood ear infection ( 28928442) Chronotype ( 30696823) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Frontal fibrosing alopecia ( 30850646) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 27863252) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Immature fraction of reticulocytes ( 32888494) Late-onset myasthenia gravis ( 26562150) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Menarche (age at onset) ( 25231870) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mumps ( 28928442) Nasopharyngeal carcinoma ( 19664746 20512145) Plantar warts ( 28928442) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Setpoint viral load in HIV-1 infection ( 26553974) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 26606652 28714469) Vitiligo ( 20410501 27723757) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		228 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SLC9A3R1 SLC9A3R2 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ	30 interacting genes: APLP2 B2M BCAP31 BUD31 CALR CANX CCR9 CD8A DEK DERL1 ERBB2 GPR35 KIR3DL2 LILRB1 LILRB2 LTB4R2 MAGEA1 MAGEA4 MEOX2 MEX3C PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17
Entrez ID		5578	3105
HPRD ID		01498	00826
Ensembl ID		ENSG00000154229	ENSG00000206503
Uniprot IDs		L7RSM7 P17252 Q7Z727	B1PKY1 B2R7U3 P04439 Q5SUL5
PDB IDs		2ELI 3IW4 4DNL 4RA4	1AKJ 1AO7 1AQD 1B0G 1B0R 1BD2 1DUY 1DUZ 1EEY 1EEZ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1JF1 1JHT 1LP9 1OGA 1P7Q 1Q94 1QEW 1QR1 1QRN 1QSE 1QSF 1QVO 1S8D 1S9W 1S9X 1S9Y 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UR7 1W72 1X7Q 2AV1 2AV7 2BCK 2BNQ 2BNR 2C7U 2CLR 2F53 2F54 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2HLA 2HN7 2J8U 2JCC 2P5E 2P5W 2PYE 2UWE 2V2W 2V2X 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2XPG 3BGM 3BH8 3BH9 3BHB 3BO8 3D25 3D39 3D3V 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HLA 3HPJ 3I6G 3I6K 3I6L 3IXA 3KLA 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MYJ 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3PWJ 3PWL 3PWN 3PWP 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3TO2 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3WL9 3WLB 4E5X 4EMZ 4EN2 4EUP 4F7M 4F7P 4F7T 4FTV 4GKN 4GKS 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4K7F 4L29 4L3C 4L3E 4MJ5 4MJ6 4MNQ 4N8V 4NNX 4NNY 4NO0 4NO2 4NO3 4NO5 4NQV 4NQX 4OV5 4QOK 4U6X 4U6Y 4UQ2 4UQ3 4WJ5 4WU5 4WU7 4WUU 5BRZ 5BS0 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0I 5C0J 5D2L 5D2N 5D9S 5DDH 5E00 5E6I 5E9D 5ENW 5EOT 5EU3 5EU4 5EU5 5EU6 5EUO 5F7D 5F9J 5FA3 5FA4 5FDW 5GRD 5GRG 5GSD 5HGA 5HGB 5HGD 5HGH 5HHM 5HHN 5HHO 5HHP 5HHQ 5HYJ 5IRO 5ISZ 5JHD 5JZI 5MEN 5MEO 5MEP 5MEQ 5MER 5N1Y 5N6B 5NHT 5NME 5NMF 5NMG 5NMH 5NMK 5NQK 5SWQ 5TEZ 5W1W 5WJL 5WJN 5WKF 5WKH 5WSH 5WWI 5WWJ 5WWU 5WXC 5WXD 5XOV 5YXN 5YXU 6AM5 6AMT 6AMU 6APN 6AT9 6D78 6D7G 6DKP 6EI2 6ENY 6EQA 6EQB 6EWA 6EWC 6EWO 6G3J 6G3K 6ID4 6J1W 6J29 6J2A 6JOZ 6JP3 6MPP 6NCA 6O9B 6O9C 6OPD 6PBH 6PTB 6PTE 6Q3K 6Q3S 6R2L 6RP9 6RPA 6RPB 6RSY 6SS7 6SS8 6SS9 6SSA
Enriched GO Terms of Interacting Partners?
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