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SLC9A3R1 and SLC22A11
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
SLC9A3R1
SLC22A11
Description
SLC9A3 regulator 1
solute carrier family 22 member 11
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Microvillus
Endomembrane System
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Filopodium
Brush Border Membrane
Microvillus Membrane
Vesicle
Stereocilium Tip
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cell Periphery
Sperm Midpiece
Plasma Membrane Protein Complex
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Apical Plasma Membrane
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Protein Binding
Beta-catenin Binding
Gamma-aminobutyric Acid Transmembrane Transporter Activity
Chloride Channel Regulator Activity
Phosphatase Binding
PDZ Domain Binding
Beta-2 Adrenergic Receptor Binding
Type 2 Metabotropic Glutamate Receptor Binding
Type 3 Metabotropic Glutamate Receptor Binding
Protein-membrane Adaptor Activity
Protein Self-association
Protein-containing Complex Binding
Myosin II Binding
Protein N-terminus Binding
Dopamine Receptor Binding
Growth Factor Receptor Binding
Inorganic Anion Exchanger Activity
Protein Binding
Organic Anion Transmembrane Transporter Activity
Sodium-independent Organic Anion Transmembrane Transporter Activity
Biological Process
Morphogenesis Of An Epithelium
Renal Sodium Ion Transport
Plasma Membrane Organization
Nuclear Migration
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Regulation Of Cell Size
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Wnt Signaling Pathway
Gland Morphogenesis
Microvillus Assembly
Actin Cytoskeleton Organization
Negative Regulation Of Cell Migration
Cellular Phosphate Ion Homeostasis
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium:proton Antiporter Activity
Bile Acid Secretion
Glutathione Transport
Positive Regulation Of Ion Transmembrane Transport
Regulation Of Excretion
Cilium Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Protein Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Establishment Of Golgi Localization
Negative Regulation Of Protein Kinase B Signaling
Gamma-aminobutyric Acid Import
Auditory Receptor Cell Stereocilium Organization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Protein-containing Complex Assembly
Renal Absorption
Negative Regulation Of ERK1 And ERK2 Cascade
Protein Localization To Plasma Membrane
Negative Regulation Of Canonical Wnt Signaling Pathway
Cerebrospinal Fluid Circulation
Renal Phosphate Ion Absorption
Import Across Plasma Membrane
Transport Across Blood-brain Barrier
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Inorganic Anion Transport
Organic Anion Transport
Urate Metabolic Process
Transmembrane Transport
Pathways
Organic anion transport
Drugs
Cefotaxime
Probenecid
Ceftriaxone
Lesinurad
Diseases
Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Dental caries (decayed and filled deciduous tooth surfaces) (
31533690
)
Fibrinogen (
20031577
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Body mass index (
32363570
)
Gout (
32238385
)
Obesity-related traits (
23251661
)
Renal underexcretion gout (
32238385
)
Serum uric acid levels (
30993211
26902266
)
Systemic lupus erythematosus (
28714469
)
Urate levels (
20884846
31578528
23263486
)
Urate levels in lean individuals (
25811787
)
Urate levels in overweight individuals (
25811787
)
Uric acid levels (
19503597
)
Interacting Genes
61 interacting genes:
ABCC2
ABCC4
ADRB2
AKAP10
AKT1
APPBP2
ATP6V1B1
ATP6V1E1
BCL10
BCL2A1
CFTR
CLCN3
CNGA2
CRABP1
CTNNB1
DLGAP4
EGFR
EZR
GNA11
GNAQ
GRK6
KCNJ1
LHCGR
LPAR2
MSN
NF2
NOS2
OPRK1
P2RY1
PAG1
PDGFRA
PDGFRB
PDZK1
PHLPP1
PLCB1
PLCB2
PRKCA
PTEN
PTH1R
RDX
RLBP1
SCN4A
SKP2
SLC13A1
SLC22A11
SLC22A4
SLC22A5
SLC22A9
SLC26A3
SLC34A1
SLC4A7
SLC4A8
SLC9A3
SLCO1A2
SLCO3A1
TBC1D10A
TRPC4
TRPC5
YAP1
YES1
ZNF468
3 interacting genes:
CAV3
PDZK1
SLC9A3R1
Entrez ID
9368
55867
HPRD ID
05406
06161
Ensembl ID
ENSG00000109062
ENSG00000168065
Uniprot IDs
O14745
Q9NSA0
PDB IDs
1G9O
1GQ4
1GQ5
1I92
1SGH
2D10
2JXO
2KJD
2KRG
2M0T
2M0U
2M0V
2OZF
4JL7
4LMM
4MPA
4N6X
4PQW
4Q3H
6RQR
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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