RNF126 and AICDA

Data Source:
BioGRID (biochemical, affinity chromatography technology, enzymatic study)

		RNF126	AICDA
Description		ring finger protein 126	activation induced cytidine deaminase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	P-body Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Deoxycytidine Deaminase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System	MRNA Processing Cytidine Deamination Negative Regulation Of Transposition Somatic Diversification Of Immunoglobulins Somatic Hypermutation Of Immunoglobulin Genes Cytidine To Uridine Editing B Cell Differentiation Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination DNA Demethylation Negative Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
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Diseases			Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	Takayasu arteritis ( 25604533)
Interacting Genes		39 interacting genes: AICDA BAG6 CDKN1A CENPP CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	6 interacting genes: APP NEDD4L PRKDC PSME3 RNF126 RPA1
Entrez ID		55658	57379
HPRD ID		11501	05585
Ensembl ID		ENSG00000070423	ENSG00000111732
Uniprot IDs		A0A024R206 A8K0Q1 Q9BV68	Q546Y9 Q6QJ80 Q7Z599 Q9GZX7
PDB IDs		2N9O 2N9P	5JJ4 5W0R 5W0U 5W0Z 5W1C
Enriched GO Terms of Interacting Partners?
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