RNF126 and FXN

Data Source:
BioGRID (enzymatic study)

		RNF126	FXN
Description		ring finger protein 126	frataxin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Population Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases			Friedreich ataxia
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Seasonality ( 25562672)
Interacting Genes		39 interacting genes: AICDA BAG6 CDKN1A CENPP CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	6 interacting genes: ACTN1 DAPP1 GOLGA6L9 PICK1 PMPCB RNF126
Entrez ID		55658	2395
HPRD ID		11501	06013
Ensembl ID		ENSG00000070423	ENSG00000165060
Uniprot IDs		A0A024R206 A8K0Q1 Q9BV68	A0A0S2Z3G4 Q16595
PDB IDs		2N9O 2N9P	1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU
Enriched GO Terms of Interacting Partners?
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