RNF126 and HMGCL

Data Source:
BioGRID (two hybrid)

		RNF126	HMGCL
Description		ring finger protein 126	3-hydroxy-3-methylglutaryl-CoA lyase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs			3-hydroxyglutaric acid
Diseases			3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)	High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		39 interacting genes: AICDA BAG6 CDKN1A CENPP CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6	9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126
Entrez ID		55658	3155
HPRD ID		11501	02003
Ensembl ID		ENSG00000070423	ENSG00000117305
Uniprot IDs		A0A024R206 A8K0Q1 Q9BV68	P35914
PDB IDs		2N9O 2N9P	2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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