OTUD5 and ARPC3

Data Source:
HPRD (two hybrid)

		OTUD5	ARPC3
Description		OTU deubiquitinase 5	actin related protein 2/3 complex subunit 3
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GO Annotations	Cellular Component	Cytosol	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity Lys63-specific Deubiquitinase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Type I Interferon Production Response To Lipopolysaccharide Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus
Pathways		Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		12 interacting genes: ARPC3 NEDD8 NONO PDCD5 POLR2A POLR2B POLR2C SUB1 TP53 TRAF3 UBC UBR5	30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		55593	10094
HPRD ID		06488	09175
Ensembl ID		ENSG00000068308	ENSG00000111229
Uniprot IDs		A0A024QZ09 Q96G74	O15145
PDB IDs		3PFY 3TMO 3TMP	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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