ARPC3 and TARS3

Data Source:
BioGRID (two hybrid)

		ARPC3	TARS3
Description		actin related protein 2/3 complex subunit 3	threonyl-tRNA synthetase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome	Cellular_component Nucleus Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Molecular_function Threonine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus	Threonyl-tRNA Aminoacylation Biological_process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576	6 interacting genes: ARPC3 ATF4 ECSIT LGALS14 TARS1 TARS2
Entrez ID		10094	123283
HPRD ID		09175	15469
Ensembl ID		ENSG00000111229	ENSG00000185418
Uniprot IDs		O15145	A2RTX5
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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