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PPP2R5D and USHBP1
Data Source:
BioGRID
(two hybrid)
PPP2R5D
USHBP1
Description
protein phosphatase 2 regulatory subunit B'delta
USH1 protein network component harmonin binding protein 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Phosphatase Activator Activity
Protein Binding
PDZ Domain Binding
Biological Process
Protein Dephosphorylation
Signal Transduction
Nervous System Development
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Protein Autophosphorylation
Positive Regulation Of Protein Dephosphorylation
Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Estimated glomerular filtration rate (
31015462
)
Mitochondrial DNA copy number (
30704525
)
Interacting Genes
18 interacting genes:
CHEK2
CLOCK
CRY1
CRY2
CSNK1E
CSNK2B
DELEC1
DYDC1
FSD2
HAND1
HAND2
PPFIA1
PPP2R1A
PPP2R1B
PPP4C
RORC
SGO1
USHBP1
234 interacting genes:
ABHD11
ABI2
ABLIM1
ACMSD
AKAP9
ANKRD33
ANKRD36BP1
ARFIP2
ARMC5
ARNT2
ASB15
ATP5PO
BCAS2
BCL10
BCL2L11
BET1
BEX2
BEX3
BFSP1
BFSP2
BICRAL
BLOC1S1
BLZF1
BORCS6
BRAT1
BRPF1
C1orf109
C1orf216
C21orf58
CBY2
CCDC103
CCDC116
CCDC120
CCDC121
CCDC146
CCDC148
CCDC187
CCDC196
CCDC197
CCDC22
CCDC24
CCDC28A
CCDC33
CCDC42
CCDC87
CCHCR1
CCNK
CDC37
CDC5L
CDKN1A
CENPP
CEP63
CEP68
CFAP206
CHCHD3
CNNM3
COPS4
COPS6
COPS8
CTNNA3
CTNNBIP1
CTTNBP2NL
CYTH4
DCTN2
DCTN3
DEPP1
DEUP1
DTNB
DYDC1
EIF4E2
ENKD1
ERCC1
EXOC7
EXOC8
FAM107A
FAM110A
FAM124B
FAM161B
FANCG
FATE1
FBF1
FCHSD2
FCRL5
FTL
GAS8
GATAD2B
GCC1
GEM
GFI1B
GIT2
GMCL2
GNG4
GOLGA6L9
GOLGA8EP
GOLGA8F
GPSM1
GPSM3
GTF2H1
HAUS1
HAUS8
HGS
HMG20A
HMG20B
HYI
IFT20
IL16
IMP3
ING3
INPP1
INTS4
ITGB3BP
KANK2
KANSL1
KIAA0753
KLC3
KLC4
KLHL38
KLHL42
KPNA2
KRT14
KRT15
KRT16
KRT19
KRT20
KRT26
KRT27
KRT28
KRT31
KRT37
KRT38
KRT40
KRT71
KRT75
KRT79
LENG1
LINC00526
MAGEB4
MCCD1
MCM7
MCRS1
MED11
MED28
MED4
MEI4
METTL15
MIIP
MKRN3
MNS1
MOS
MRPS23
MXI1
MYOG
MYOZ1
NCAPH2
NDC80
NDE1
NECAB2
NEFL
NOC4L
NUP62
ODAD3
OIP5
PARVG
PAX6
PBX4
PICK1
PKN1
PKNOX2
PMF1
POLM
POP5
PPP1R12C
PPP1R7
PPP2R5A
PPP2R5D
PRC1
PRKAA2
PRR5
QARS1
RASAL2
RCOR3
RECK
RIBC1
RIBC2
RINT1
RNF20
RTP5
SAPCD2
SAT1
SCNM1
SCT
SEC14L4
SEMA4C
SERTAD3
SH2D4A
SHC3
SMARCD1
SMARCE1
SOHLH1
SPG21
SRI
STX11
SYNJ2BP
TASOR2
TCEANC
TCHP
TEKT1
THADA
THOC1
TIMM13
TPRX1
TRIM54
TRIML2
TSG101
TTC23
TTC9C
TTLL10
TUBGCP4
TXLNA
TXLNB
UBE2W
UBXN11
USH1C
USP2
VPS28
ZBTB42
ZFHX3
ZFYVE26
ZNF417
ZNF483
ZNF655
ZNF688
ZNF765
ZNRF2P1
Entrez ID
5528
83878
HPRD ID
09039
18276
Ensembl ID
ENSG00000112640
ENSG00000130307
Uniprot IDs
A0A024RD11
Q14738
A0A024R7H3
B4DUE8
G8JLM4
Q8N6Y0
Q8N8Y1
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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