USHBP1 and THADA

Data Source:
BioGRID (two hybrid)

		USHBP1	THADA
Description		USH1 protein network component harmonin binding protein 1	THADA armadillo repeat containing
Image		No pdb structure
GO Annotations	Cellular Component		Cytosol Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding PDZ Domain Binding	Protein Binding
	Biological Process		TRNA Methylation Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Lipid Homeostasis Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Adaptive Thermogenesis
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525)	Alopecia areata ( 25337690) Apolipoprotein B levels ( 32203549) Blood glucose levels ( 31928498) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Diastolic blood pressure ( 31469255) DNA methylation (variation) ( 23725790) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hair morphology ( 19896111) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Latent autoimmune diabetes ( 30254083) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Mitochondrial DNA levels ( 25240745) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 22190364) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Orofacial clefts ( 20023658 22863734) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 30566500 26416764 21151128) Prostate cancer ( 31562322 19767753) Red blood cell count ( 32888494) Response to amphetamines ( 22952603) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 18372903 30054458 29358691 30297969 29632382 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Viral capsid antigen IgG seropositivity ( 29868224)
Interacting Genes		234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf109 C1orf216 C21orf58 CBY2 CCDC103 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GAS8 GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1	2 interacting genes: POU6F2 USHBP1
Entrez ID		83878	63892
HPRD ID		18276	18177
Ensembl ID		ENSG00000130307	ENSG00000115970
Uniprot IDs		A0A024R7H3 B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1	Q6YHU6
PDB IDs			5T6Y
Enriched GO Terms of Interacting Partners?
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