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PTPA and F3
Data Source:
BioGRID
(enzymatic study)
PTPA
F3
Description
protein phosphatase 2 phosphatase activator
coagulation factor III, tissue factor
Image
GO Annotations
Cellular Component
Protein Phosphatase Type 2A Complex
Nucleus
Nucleoplasm
Cytoplasm
Calcium Channel Complex
Extracellular Exosome
Extracellular Space
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Intrinsic Component Of External Side Of Plasma Membrane
Collagen-containing Extracellular Matrix
Serine-type Peptidase Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein Tyrosine Phosphatase Activator Activity
ATPase Activity
Protein Phosphatase Regulator Activity
Protein Homodimerization Activity
Protein Phosphatase 2A Binding
Protease Binding
Serine-type Endopeptidase Activity
Cytokine Receptor Activity
Protein Binding
Phospholipid Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Mitotic Spindle Organization
Negative Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Protein Dephosphorylation
Positive Regulation Of Apoptotic Process
Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Endothelial Cell Proliferation
Activation Of Plasma Proteins Involved In Acute Inflammatory Response
Activation Of Blood Coagulation Via Clotting Cascade
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Blood Coagulation
Blood Coagulation, Extrinsic Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Protein Processing
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Angiogenesis
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Pathways
Extrinsic Pathway of Fibrin Clot Formation
NGF-stimulated transcription
Drugs
Coagulation factor VIIa Recombinant Human
rNAPc2
2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA
[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid
Coagulation factor VII human
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
D-dimer levels (
21502573
)
End-stage coagulation (
23381943
)
Smoking status (heavy vs never) (
26423011
)
Type 2 diabetes (
22238593
)
Interacting Genes
28 interacting genes:
AKT1
AMOT
APP
AURKB
CCDC125
CCNE1
CCNG1
CCNG2
CSNK2A1
CYLD
DTD1
EIF4EBP1
F3
FOXO3
GRIN3A
H2AX
HDAC4
KISS1R
MAPT
MID1
NIF3L1
PPP2R1A
PPP2R3A
PRKCB
RACGAP1
SPG21
SRC
SULT4A1
8 interacting genes:
F10
F7
FANCB
FLNA
HPCAL4
MDM2
PLG
PTPA
Entrez ID
5524
2152
HPRD ID
02858
00603
Ensembl ID
ENSG00000119383
ENSG00000117525
Uniprot IDs
B4DZF8
F6WIT2
Q15257
P13726
PDB IDs
2G62
2HV6
2HV7
2IXM
4LAC
4NY3
1AHW
1BOY
1DAN
1FAK
1J9C
1JPS
1NL8
1O5D
1TFH
1UJ3
1W0Y
1W2K
1WQV
1WSS
1WTG
1WUN
1WV7
1Z6J
2A2Q
2AEI
2AER
2B7D
2B8O
2C4F
2CEF
2CEH
2CEZ
2CFJ
2EC9
2F9B
2FIR
2FLB
2FLR
2HFT
2PUQ
2ZP0
2ZWL
2ZZU
3ELA
3TH2
3TH3
3TH4
4IBL
4M7L
4YLQ
4Z6A
4ZMA
5W06
6R2W
Enriched GO Terms of Interacting Partners
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