FBXL12 and CDKN1C

Data Source:
HPRD (in vivo)

		FBXL12	CDKN1C
Description		F-box and leucine rich repeat protein 12	cyclin dependent kinase inhibitor 1C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol SCF Ubiquitin Ligase Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Post-translational Protein Modification Regulation Of Cell Cycle	Cell Cycle Arrest Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases			Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Pursuit maintenance gain ( 29064472)	Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061)
Interacting Genes		19 interacting genes: A2M ALDH3A1 APOE CDC37 CDKN1C DOCK8 ECSIT FBF1 FXYD3 GEMIN4 LNX1 MAST1 PSEN1 PSEN2 PSME3 RNF32 SMAD1 TGFBR1 UBE2D3	10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2
Entrez ID		54850	1028
HPRD ID		12363	02913
Ensembl ID		ENSG00000127452	ENSG00000129757
Uniprot IDs		Q9NXK8	P49918
PDB IDs
Enriched GO Terms of Interacting Partners?
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