CDKN1C and MYOD1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		CDKN1C	MYOD1
Description		cyclin dependent kinase inhibitor 1C	myogenic differentiation 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Myofibril
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Cell Cycle Arrest Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Chromatin Binding Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Binding Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Myogenesis Myogenesis
Drugs
Diseases		Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061)	Body mass index ( 26426971) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	67 interacting genes: AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		1028	4654
HPRD ID		02913	01166
Ensembl ID		ENSG00000129757	ENSG00000129152
Uniprot IDs		P49918	P15172
PDB IDs
Enriched GO Terms of Interacting Partners?
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