TRIM44 and TRIM69

Data Source:
BioGRID (two hybrid)

		TRIM44	TRIM69
Description		tripartite motif containing 44	tripartite motif containing 69
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Protein Stabilization Negative Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of NIK/NF-kappaB Signaling	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Photic sneeze reflex ( 27182965) Response to antipsychotic therapy (extrapyramidal side effects) ( 19875103)	Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		9 interacting genes: APP FBXO7 HINFP MORN4 NEDD4 PBX3 PICK1 TRIM10 TRIM69	53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483
Entrez ID		54765	140691
HPRD ID		15561	11518
Ensembl ID		ENSG00000166326	ENSG00000185880
Uniprot IDs		Q96DX7	H0YL66 Q86WT6
PDB IDs			4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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