PAF1 and LEO1

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PAF1	LEO1
Description		PAF1 homolog, Paf1/RNA polymerase II complex component	LEO1 homolog, Paf1/RNA polymerase II complex component
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Cdc73/Paf1 Complex Cell Junction Transcriptionally Active Chromatin	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Nucleosome Positioning Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of MRNA 3'-end Processing Histone H2B Ubiquitination Protein Localization To Nucleus Negative Regulation Of Myeloid Cell Differentiation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition	Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Beta-catenin-TCF Complex Assembly
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: ENO1 ERCC6 FXR2 H1-2 H3C1 HSPB1 KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 SUMO2 TCEA1 TULP3	9 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 PAF1 POLR2A TCEA1 TCEA3
Entrez ID		54623	123169
HPRD ID		10140	11231
Ensembl ID		ENSG00000006712	ENSG00000166477
Uniprot IDs		A0A024R0H6 Q8N7H5	Q8WVC0
PDB IDs		4M6T 5ZYQ 6GMH 6TED	4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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