FXYD6 and C4BPA

Data Source:
BioGRID (two hybrid)

		FXYD6	C4BPA
Description		FXYD domain containing ion transport regulator 6	complement component 4 binding protein alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle
	Molecular Function	Molecular_function Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity	RNA Binding Protein Binding
	Biological Process	Biological_process Ion Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Complement Activation, Classical Pathway Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Regulation of Complement cascade
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)	Blood protein levels ( 29875488) C4b binding protein levels ( 20212171) Mean platelet volume ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		65 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35C2 SLC35E1 SLC35E3 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119	9 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1
Entrez ID		53826	722
HPRD ID		09456	00403
Ensembl ID		ENSG00000137726	ENSG00000123838
Uniprot IDs		A0A024R3J8 Q9H0Q3	P04003
PDB IDs			2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q
Enriched GO Terms of Interacting Partners?
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