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SERPINA4 and ILK
Data Source:
BioGRID
(two hybrid)
SERPINA4
ILK
Description
serpin family A member 4
integrin linked kinase
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Platelet Dense Granule Lumen
Extracellular Exosome
Stress Fiber
Nucleoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Sarcomere
Lamellipodium
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Platelet Degranulation
Negative Regulation Of Endopeptidase Activity
Cell Morphogenesis
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Positive Regulation Of Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Cell Junction Assembly
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Phosphorylation
Positive Regulation Of Transcription, DNA-templated
Platelet Aggregation
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
Platelet degranulation
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Cell-extracellular matrix interactions
Drugs
Zinc
Copper
Zinc acetate
Diseases
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Vaspin levels (
22907691
)
Malaria (
31844061
)
Interacting Genes
13 interacting genes:
CTSD
GADD45G
ILK
KLK1
KLK2
MAP4K2
MAPK6
NR4A1
RASA1
TAB1
TNFRSF14
TNNT1
YAE1
42 interacting genes:
AKT1
CASP8
CASP9
CAV1
CKB
FERMT1
FERMT2
FERMT3
GSK3B
ILKAP
ITGB1
ITGB2
ITGB3
LIMS1
LIMS2
MATK
MBP
MIPEP
NCK2
NOTCH1
PARVA
PARVB
PARVG
PDPK1
PPP1R12A
PTPN11
PXN
RICTOR
RNF19A
RPL13
SERPINA4
SHC1
SNRNP35
SUMO2
TMSB4X
TRIM27
TWF2
ZBTB48
ZNF133
ZNF205
ZNF579
ZNF746
Entrez ID
5267
3611
HPRD ID
01004
03842
Ensembl ID
ENSG00000100665
ENSG00000166333
Uniprot IDs
A0A024R6I9
P29622
Q13418
V9HWF0
PDB IDs
6F02
2KBX
3F6Q
3IXE
3KMU
3KMW
3REP
4HI8
4HI9
6MIB
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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