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PDHA1 and PDK3
Data Source:
HPRD
(in vitro)
PDHA1
PDK3
Description
pyruvate dehydrogenase E1 subunit alpha 1
pyruvate dehydrogenase kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Mitochondrion
Mitochondrial Matrix
Mitochondrial Pyruvate Dehydrogenase Complex
Pyruvate Dehydrogenase Complex
Nucleolus
Mitochondrion
Mitochondrial Matrix
Molecular Function
Pyruvate Dehydrogenase (acetyl-transferring) Activity
Protein Binding
Pyruvate Dehydrogenase (NAD+) Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity
Protein Binding
ATP Binding
Biological Process
Glucose Metabolic Process
Acetyl-CoA Biosynthetic Process From Pyruvate
Pyruvate Metabolic Process
Tricarboxylic Acid Cycle
Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Glucose Metabolic Process
Protein Phosphorylation
Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate
Regulation Of Glucose Metabolic Process
Peptidyl-serine Phosphorylation
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Glucose Stimulus
Cellular Response To Fatty Acid
Hypoxia-inducible Factor-1alpha Signaling Pathway
Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid
Drugs
NADH
Radicicol
Dihydrolipoic Acid
Diseases
Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS
Metabolite levels (
23823483
)
Malaria (
31844061
)
Interacting Genes
9 interacting genes:
DLAT
EIF6
HSD17B10
PDHB
PDK1
PDK2
PDK3
PDK4
PDP1
4 interacting genes:
APP
DLAT
EGFR
PDHA1
Entrez ID
5160
5165
HPRD ID
02420
03956
Ensembl ID
ENSG00000131828
ENSG00000067992
Uniprot IDs
A0A024RBX9
P08559
Q15120
PDB IDs
1NI4
2OZL
3EXE
3EXF
3EXG
3EXH
3EXI
6CER
6CFO
1Y8N
1Y8O
1Y8P
2PNR
2Q8I
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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