PDHA1 and DLAT

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		PDHA1	DLAT
Description		pyruvate dehydrogenase E1 subunit alpha 1	dihydrolipoamide S-acetyltransferase
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GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Protein Phosphopantetheinylation Sleep
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		NADH	NADH Radicicol Dihydrolipoic Acid
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		5160	1737
HPRD ID		02420	10578
Ensembl ID		ENSG00000131828	ENSG00000150768
Uniprot IDs		A0A024RBX9 P08559	P10515 Q86YI5
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55
Enriched GO Terms of Interacting Partners?
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