PDK3 and DLAT

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PDK3	DLAT
Description		pyruvate dehydrogenase kinase 3	dihydrolipoamide S-acetyltransferase
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GO Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding
	Biological Process	Glucose Metabolic Process Protein Phosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Protein Phosphopantetheinylation Sleep
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		Radicicol Dihydrolipoic Acid	NADH Radicicol Dihydrolipoic Acid
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Malaria ( 31844061)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: APP DLAT EGFR PDHA1	7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		5165	1737
HPRD ID		03956	10578
Ensembl ID		ENSG00000067992	ENSG00000150768
Uniprot IDs		Q15120	P10515 Q86YI5
PDB IDs		1Y8N 1Y8O 1Y8P 2PNR 2Q8I	1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55
Enriched GO Terms of Interacting Partners?
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