DLAT and PDK4

Data Source:
HPRD (in vitro)

		DLAT	PDK4
Description		dihydrolipoamide S-acetyltransferase	pyruvate dehydrogenase kinase 4
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Intracellular Membrane-bounded Organelle Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity Identical Protein Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Protein Phosphopantetheinylation Sleep	Glucose Metabolic Process Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Response To Starvation Regulation Of Bone Resorption Regulation Of Fatty Acid Oxidation Cellular Response To Fatty Acid Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		NADH Radicicol Dihydrolipoic Acid	Tretinoin 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Brain morphology (MOSTest) ( 32665545)	Refractive error ( 32231278)
Interacting Genes		7 interacting genes: PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3	4 interacting genes: DLAT PDHA1 PLEKHF2 TRIM63
Entrez ID		1737	5166
HPRD ID		10578	03957
Ensembl ID		ENSG00000150768	ENSG00000004799
Uniprot IDs		P10515 Q86YI5	A4D1H4 Q16654
PDB IDs		1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55	2E0A 2ZDX 2ZDY 2ZKJ 3D2R
Enriched GO Terms of Interacting Partners?
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