UBE2S and HERC1

Data Source:
BioGRID (pull down)

		UBE2S	HERC1
Description		ubiquitin conjugating enzyme E2 S	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol	Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Neuron Projection Development Regulation Of Catalytic Activity Neuromuscular Process Controlling Balance
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		42 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CCNB1 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 VHL ZRANB1	12 interacting genes: BAK1 EP300 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S
Entrez ID		27338	8925
HPRD ID		15603	06894
Ensembl ID		ENSG00000108106	ENSG00000103657
Uniprot IDs		Q16763	A0A024R5W0 Q15751
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK 6S96 6S98	4O2W 4QT6
Enriched GO Terms of Interacting Partners?
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