PLEKHO1 and FLNB

Data Source:
BioGRID (two hybrid)

		PLEKHO1	FLNB
Description		pleckstrin homology domain containing O1	filamin B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Integral Component Of Membrane Z Disc Neuron Projection Neuronal Cell Body Extracellular Exosome
	Molecular Function	Protein Binding	RNA Binding Actin Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis	Signal Transduction Muscle Organ Development Actin Cytoskeleton Organization Cell Differentiation
Pathways			ISG15 antiviral mechanism
Drugs
Diseases			Spondylocarpotarsal synostosis syndrome FLNB-related disorders, including: ; Atelostogenesis, type I; Boomerang dysplasia; Atelosteogenesis, type III; Larsen syndrome
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Eating disorders (purging via substances) ( 23568457) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31217584) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171 28073927) Pulse pressure ( 30578418) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Systemic sclerosis ( 31672989) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	22 interacting genes: ASB2 ATF7IP ERBB2 FBLIM1 FLNA GP1BA HSPB1 ITGB1 ITGB3 ITGB6 MLH1 MYBPC2 NPHP1 PLEKHO1 PSEN1 PSEN2 RAD21 SMURF2 SUMO2 TRIM55 TSC22D2 TSHR
Entrez ID		51177	2317
HPRD ID		12217	04543
Ensembl ID		ENSG00000023902	ENSG00000136068
Uniprot IDs		Q53GL0 Q5T4P9	O75369
PDB IDs		3AA1	2DI8 2DI9 2DIA 2DIB 2DIC 2DJ4 2DLG 2DMB 2DMC 2E9I 2E9J 2EE6 2EE9 2EEA 2EEB 2EEC 2EED 2WA5 2WA6 2WA7 3FER 4B7L 5DCP
Enriched GO Terms of Interacting Partners?
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