EXOSC1 and DMRTB1

Data Source:
BioGRID (two hybrid)

		EXOSC1	DMRTB1
Description		exosome component 1	DMRT like family B with proline rich C-terminal 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription By RNA Polymerase II Germ Cell Development Sex Differentiation
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Cerebrospinal fluid AB1-42 levels ( 28247064) Response to statin therapy ( 20339536)
Interacting Genes		34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76	40 interacting genes: C1orf94 CCND3 CDKN2D CTBP1 CTBP2 EWSR1 EXOSC1 EXOSC5 EYA2 FXR2 HNRNPUL1 IL16 INCA1 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP8-1 LENG8 NCKIPSD NEDD9 NIF3L1 PARD6G PEF1 PKP2 PRMT2 QKI RAMAC RBFOX1 RBFOX2 RBM14 RBPMS RPA2 SH3RF1 SLAIN1 SORBS3 TENT5A TLE5 TOX TSG101 VASP
Entrez ID		51013	63948
HPRD ID		16223	16828
Ensembl ID		ENSG00000171311	ENSG00000143006
Uniprot IDs		B1AMU3 Q9Y3B2	I6L9A0 Q96MA1
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?