EXOSC1 and KCTD1

Data Source:
BioGRID (two hybrid)

		EXOSC1	KCTD1
Description		exosome component 1	potassium channel tetramerization domain containing 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytosol Centriolar Satellite Intercellular Bridge
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Sudden cardiac arrest ( 21658281)
Interacting Genes		34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76	19 interacting genes: EPM2AIP1 EXOSC1 KCTD15 LMO1 LMO3 LNX1 MORF4L2 NTAQ1 PICK1 POLR1C PRKAA2 PSMA1 SDCBP TGM7 TRAPPC2 TRAPPC2B UBASH3A UBE2I ZBTB25
Entrez ID		51013	284252
HPRD ID		16223	11059
Ensembl ID		ENSG00000171311	ENSG00000134504
Uniprot IDs		B1AMU3 Q9Y3B2	A0A024RC45 A0A2U3U043 Q719H9
PDB IDs		2NN6 6D6Q 6D6R 6H25	5BXB 5BXD 6S4L
Enriched GO Terms of Interacting Partners?
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