EXOSC1 and ASB9

Data Source:
BioGRID (two hybrid)

		EXOSC1	ASB9
Description		exosome component 1	ankyrin repeat and SOCS box containing 9
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol	Mitochondrion Cytosol
	Molecular Function	RNA Binding Exoribonuclease Activity Protein Binding	Protein Binding
	Biological Process	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: A2M APP ASB9 CDC37 DDIT4L DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FHL3 KCTD1 LNX1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 PTEN RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1 ZNF143 ZNF76	12 interacting genes: ACTN3 ASB13 CKB CKM CKMT1A CKMT1B EXOSC1 HIF1AN LCK PLCG2 RELA UBE2D1
Entrez ID		51013	140462
HPRD ID		16223	06452
Ensembl ID		ENSG00000171311	ENSG00000102048
Uniprot IDs		B1AMU3 Q9Y3B2	A0A024RBW2 A0A024RBW7 A0A024RBZ4 Q96DX5
PDB IDs		2NN6 6D6Q 6D6R 6H25	3D9H 3ZKJ 3ZNG 6V9H
Enriched GO Terms of Interacting Partners?
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