SLC35C2 and TAP1

Data Source:
BioGRID (two hybrid)

		SLC35C2	TAP1
Description		solute carrier family 35 member C2	transporter 1, ATP binding cassette subfamily B member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Antiporter Activity	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Gene Expression UDP-glucose Transmembrane Transport Protein O-linked Fucosylation Positive Regulation Of Notch Signaling Pathway	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport Anion Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways			ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS			Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		91 interacting genes: ACSL5 ADIPOQ AGPAT3 AGPAT4 APOD ARL6IP1 ASGR1 ATP13A1 BCL2L2 BMP10 C14orf180 C2 C4orf3 CCDC167 CLDN19 CMTM5 CNIH1 COL4A5 CREB3 CREB3L1 CYB561 CYBC1 DNAJC30 EFNA5 EMP3 FAM3C FDFT1 FFAR2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP5 GOLT1A GPR152 ITGAM LAT LEPROTL1 LHFPL5 LPAR3 MAL MAL2 MALL MS4A1 NRM ORMDL1 ORMDL3 PDCD1LG2 PEX16 PLN PLP2 PNLIPRP1 PRB1 RUSF1 SACM1L SEC22A SEC22B SELENOK SERP1 SLC10A6 SLC12A7 SLC30A3 SLC35F1 SLC66A1 SMCO4 SSMEM1 STRIT1 STX3 SYNDIG1 SYS1 TAP1 THBD TMEM107 TMEM14B TMEM239 TMEM31 TMEM50B TMEM65 TMEM86A TPRG1 TSNARE1 TSPAN2 TSPAN33 TVP23B UNC93B1 UPK1B VAPB VEGFA VTI1B YIF1A YIPF4 YIPF6	27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35C2 SSMEM1 TAP2 TAPBP TDP2 TMEM14B
Entrez ID		51006	6890
HPRD ID		15371	01359
Ensembl ID		ENSG00000080189	ENSG00000168394
Uniprot IDs		B7Z6R4 Q9NQQ7	A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3
PDB IDs			1JJ7 5U1D
Enriched GO Terms of Interacting Partners?
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