IGFBP4 and HK3

Data Source:
HPRD (in vitro, two hybrid)

		IGFBP4	HK3
Description		insulin like growth factor binding protein 4	hexokinase 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Mitochondrion Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity
	Biological Process	Regulation Of Cell Growth Inflammatory Response Signal Transduction Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Cellular Glucose Homeostasis Fructose 6-phosphate Metabolic Process Glycolytic Process Neutrophil Degranulation Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Neutrophil degranulation Glycolysis
Drugs
Diseases
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Uterine fibroids ( 30194396) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF	10 interacting genes: ATF4 GRN HPGDS IGFBP4 LEP MEOX2 MITF PPP2CB PTGDS ZBTB17
Entrez ID		3487	3101
HPRD ID		00900	00806
Ensembl ID		ENSG00000141753	ENSG00000160883
Uniprot IDs		A0A024R1U8 P22692	A0A024R7R1 P52790
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	3HM8
Enriched GO Terms of Interacting Partners?
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