NPY and NPY2R

Data Source:
HPRD (in vivo)

		NPY	NPY2R
Description		neuropeptide Y	neuropeptide Y receptor Y2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Synapse Neuronal Dense Core Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Cilium Non-motile Cilium
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding	Peptide YY Receptor Activity Neuropeptide Y Receptor Activity Calcium Channel Regulator Activity Protein Binding Signaling Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation	Behavioral Fear Response Positive Regulation Of Peptide Secretion Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Nitric Oxide Mediated Signal Transduction Aging Locomotory Behavior Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Nervous System Process Positive Regulation Of Dopamine Secretion Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Secretion Negative Regulation Of Secretion Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Excitatory Postsynaptic Potential Negative Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Phentermine 2-aminoisobutyric acid L-tyrosinamide	Cysteamine Peptide YY (3-36) Obinepitide
Diseases
GWAS		Adult body size ( 32376654) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Vitamin D levels ( 25208829)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Premature menopause in childhood cancer survivors ( 29432556)
Interacting Genes		16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2	4 interacting genes: NPY PYY RGS12 TRARG1
Entrez ID		4852	4887
HPRD ID		01214	01216
Ensembl ID		ENSG00000122585	ENSG00000185149
Uniprot IDs		A4D158 P01303	P49146
PDB IDs		1QFA 1RON	2IK3
Enriched GO Terms of Interacting Partners?
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